A Review on: Efficient Method for Mining Frequent Itemsets on Temporal Data

Temporal data can hold time-stamped information that affects the results of data mining. Customary strategies for finding frequent itemsets accept that datasets are static; also the instigated rules are relevant over the whole dataset. In any case, this is not the situation when data is temporal. The work is done to enhance the proficiency of mining frequent itemsets on temporal data. The patterns can hold in either all or, then again a portion of the intervals. It proposes another method with respect to time interval is called as frequent itemsets mining with time cubes. The concentration is building up an efficient algorithm for this mining issue by broadening the notable a priori algorithm. The thought of time cubes is proposed to handle different time hierarchies. This is the route by which the patterns that happen intermittently, amid a time interval or both, are perceived. Another thickness limit is likewise proposed to take care of the overestimating issue of time periods and furthermore ensure that found patterns are valid

A Review on: Efficient Method for Mining Frequent Itemsets on Temporal Data

Temporal data can hold time-stamped information that affects the results of data mining. Customary strategies for finding frequent itemsets accept that datasets are static; also the instigated rules are relevant over the whole dataset. In any case, this is not the situation when data is temporal. The work is done to enhance the proficiency of mining frequent itemsets on temporal data. The patterns can hold in either all or, then again a portion of the intervals. It proposes another method with respect to time interval is called as frequent itemsets mining with time cubes. The concentration is building up an efficient algorithm for this mining issue by broadening the notable a priori algorithm. The thought of time cubes is proposed to handle different time hierarchies. This is the route by which the patterns that happen intermittently, amid a time interval or both, are perceived. Another thickness limit is likewise proposed to take care of the overestimating issue of time periods and furthermore ensure that found patterns are valid

Functional Analysis of Retinitis Pigmentosa 2 (RP2) Protein Reveals Variable Pathogenic Potential of Disease-Associated Missense Variants

Genetic mutations are frequently associated with diverse phenotypic consequences, which limits the interpretation of the consequence of a variation in patients. Mutations in the retinitis pigmentosa 2 (RP2) gene are associated with X-linked RP, which is a phenotypically heterogenic form of retinal degeneration. The purpose of this study was to assess the functional consequence of disease-associated mutations in the RP2 gene using an in vivo assay. Morpholino-mediated depletion of rp2 in zebrafish resulted in perturbations in photoreceptor development and microphthalmia (small eye). Ultrastructural and immunofluorescence analyses revealed defective photoreceptor outer segment development and lack of expression of photoreceptor-specific proteins. The retinopathy phenotype could be rescued by expressing the wild-type human RP2 protein. Notably, the tested RP2 mutants exhibited variable degrees of rescue of rod versus cone photoreceptor development as well as microphthalmia. Our results suggest that RP2 plays a key role in photoreceptor development and maintenance in zebrafish and that the clinical heterogeneity associated with RP2 mutations may, in part, result from its potentially distinct functional relevance in rod versus cone photoreceptors

Development of a new connector for double layer space grids

Connection of the space grid elements by using connectors is one of the most common practices for construction of space structures. These connectors usually involve higher fabrication cost due to their complex geometry. To address this issue, in the present work, a new solid connector with simple geometry has been developed by truncating the corners of a cube, and is named as Truncated Hexahedron (THH). The experimental, theoretical and analytical studies have been carried out to obtain the stresses for THH connector. An instrumented axial loading test has been performed on actual THH connector, and the load-stress relationship has been obtained from load and strain measurement. A manual finite element analysis has also been carried out for theoretical computation of the stresses in the connector. Further, the THH connector has been modelled and analysed using ANSYS software and the obtained results have been compared with experimental and theoretically computed results. Subsequently, in order to assess the performance of THH connector in comparison to a standard connector (Spherical connector), a double layer grid has been analysed considering both Spherical and THH connectors at each joint of the grid separately, and it has been observed that the maximum principal stresses in both the connectors are mostly comparable. Hence, the newly developed THH connector can be considered to be as efficient as the Spherical connector. The study opens up a possibility of resorting to a new compatible connector for space grid structures, which can be easily manufactured due to its uncomplicated geometry, making it comparatively cheaper and quicker for fabrication

Conjugated Polymeric Liposomes: A Hybrid Carrier for Contemporary Drug Delivery

Liposomes are artificial vesicles encapsulating the drug moiety. The structural adaptability of liposomes has been employed to make them drug carriers for smart delivery systems, improving bioavailability, stability, target delivery, etc. However, conventional liposomes have some drawbacks, such as limited payload, shorter in vivo circulatory lifespan, unregulated releasing properties, rapid clearance from bloodstream, etc. Polymeric modification of the liposomes addressed and effectively overcame all the drawbacks of conventional liposomes. Polymeric materials offer indefinite structural diversity, thus a substantial portion of the materials has been employed for drug-targeting methods and controlled drug release. Conjugation of liposomes and polymers develops a hybrid vesicle with intermediary physicochemical and stimulus responsive properties (pH, temperature, etc.). The reliability of liposomes with respect to pH, nature of drug moiety, enzyme, and immune response can be strengthened by polymers. Polymer modified liposomes also enhance the pharmacokinetic and pharmacodynamic profile of the drug moiety. The form of polymer, cross-linking agent, interaction, and bonding used during polymerized modification of liposomes all have an impact on their activity. According to the extensive review of the literature that is accessible in the different data sources, research in this field is proactively involved in the synthesis of newer polymeric materials, and the supramolecular structuring of the different chemicals

Conjugated Polymeric Liposomes: A Hybrid Carrier for Contemporary Drug Delivery

Liposomes are artificial vesicles encapsulating the drug moiety. The structural adaptability of liposomes has been employed to make them drug carriers for smart delivery systems, improving bioavailability, stability, target delivery, etc. However, conventional liposomes have some drawbacks, such as limited payload, shorter in vivo circulatory lifespan, unregulated releasing properties, rapid clearance from bloodstream, etc. Polymeric modification of the liposomes addressed and effectively overcame all the drawbacks of conventional liposomes. Polymeric materials offer indefinite structural diversity, thus a substantial portion of the materials has been employed for drug-targeting methods and controlled drug release. Conjugation of liposomes and polymers develops a hybrid vesicle with intermediary physicochemical and stimulus responsive properties (pH, temperature, etc.). The reliability of liposomes with respect to pH, nature of drug moiety, enzyme, and immune response can be strengthened by polymers. Polymer modified liposomes also enhance the pharmacokinetic and pharmacodynamic profile of the drug moiety. The form of polymer, cross-linking agent, interaction, and bonding used during polymerized modification of liposomes all have an impact on their activity. According to the extensive review of the literature that is accessible in the different data sources, research in this field is proactively involved in the synthesis of newer polymeric materials, and the supramolecular structuring of the different chemicals

Forensic Speaker RecognitionLaw Enforcement and Counter-Terrorism /

XXI, 540 p.online resource